Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03614k

De novo design of constrained and sequence-independent peptide scaffolds with topologically-formidable disulfide connectivities† †Electronic supplementary information (ESI) available: Detailed experimental section, characterization of peptides, tryptic digestion HPLC and MS analysis of disulfide pairing in peptides (Fig. S1–S50). See DOI: 10.1039/c7sc03956e

Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization† †Electronic supplementary information (ESI) available: Experimental procedures, list of all the synthesized peptides and their % hIAPP fibrillization inhibition, MTT cytotoxicity assay, crystallization, details of X-ray structure determination, in silico docking of FGAΔFI with hIAPP, CD studies, Tables S1–S4, and Fig. S1–S6. CCDC 822015 and 904790. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3cc38982kClick here for additional data file. Click here for additional data file.

hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity.

Mixed valence mono- and hetero-metallic grid catenanes† †Electronic supplementary information (ESI) available: Details of the CSD database search, additional crystallographic information on 3–6 with relevant tables, EDS analysis and EDS plots. CCDC 1054509–1054512. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc01851j Click here for additional data file. Click here for additional data file.

Here, we report on the multicomponent self-assembly and single crystal X-ray diffraction study of a series of three interlocked mixed valence monoand hetero-metallic [2]-catenanes made of [2 2] metallo-grids. They show unique structural features and highlight the essential roles of both the Cu(II)/Cu(I) pair and of the conformationally adaptable organic ligands for achieving catenation of grids.

Hydrocarbon constrained peptides – understanding preorganisation and binding affinity† †Electronic supplementary information (ESI) available. CCDC 1057141. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc04048e Click here for additional data file. Click here for additional data file.

Hydrocarbon Constrained Peptides – Understanding Preorganization and Binding Affinity Jennifer A. Miles, David J. Yeo, Philip Rowell, Silvia Rodriguez-Marin, Christopher M. Pask, Stuart L. Warriner, Thomas A. Edwards,* Andrew J. Wilson* School of Chemistry, Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9...

Tuning the stereo-hindrance of a curcumin scaffold for the selective imaging of the soluble forms of amyloid beta species† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc02050c